ECLA-VENT

The acute respiratory syndrome (ARDS) is a life-threatening syndrome, which requires in severe cases the use of extracorporeal lung assist systems (ECLA). These ECLA systems support the damaged respiratory system via additional blood oxygenation (ECMO: extracorporal membrane oxygenation).

Since this method of treatment is cost-intensive and holds a high risk for complications, it is solely used as ultima ratio method. An automation of the therapy could increase its applicability significantly. Essential aspects would be the reduction of the workload of the staff and of the reaction time to complications. Additionally it allows a more elaborated treatment, for example by continuous adaption of the ventilation and oxygenation with respect to a patient-related strategy.

This motivation holds a range of topics for research, which are in the focus of the ECLA-VENT project. This project is part of the “Smart Life Support 2.0” framework, which is funded by the German Research Foundation (DFG).

Project Partners

Project Objectives

The main goal of our project is the reduction of the risk for patients and the optimization of the efficiency of the therapy by dynamical adaption of the treatment’s parameters. Therefore we develop in cooperation with our project partners a combined system for ventilation and oxygenation, which is based upon an intelligent embedded closed control loop.

In the focus of our project partners is the development of a cooperative closed control loop, which allows more complex strategies during the treatment and an improvement of the lung protection. Our focus of research is the safety and reliability of the embedded system. The interconnection of the closed-loop control and the physiology of the patient leads to a great number of nonlinear dependencies. Regarding to this additional safety demands must be considered and the potential of conflict of the safety goals must be analyzed. The safety mechanisms to fulfill these demands should not only restrict the system, but interact with respect to the needs of the patient. The results of the previous project “SmartECLA” will be used as basis.

Overview:

  • definition, verification and implementation of an overall safety concept with respect to the cooperative closed-loop control
    • implementation of the ventilation into the present safety concept
    • analysis of safety-critical states by hybrid system models
    • structured evaluation of conflicts between safety goals by risk analysis
    • development of conflict solving strategies
  • formulation of a design pattern catalogue to assist closed-loop control development by defined interfaces

Publications

Publications written under the framework of the SmartECLA project


Publikations-Export
[BMK+17]
PDFBIB
Brendle, C., Mülders, T., Kühn, J., Janisch, T., Kopp, R., Rossaint, R., Stollenwerk, A., Kowalewski, S., Misgeld, B., Leonhardt, S., and Walter, M., "Physiological closed-loop control of mechanical ventilation and extracorporeal membrane oxygenation”", Biomedical Engineering / Biomedizinische Technik, 2017, To appear

Physiological closed-loop control of mechanical ventilation and extracorporeal membrane oxygenation”

Bibtex entry :

@article { BMK+17,
	author = { Brendle, C. and M{\"u}lders, T. and K{\"u}hn, J. and
		Janisch, T. and Kopp, R. and Rossaint, R. and Stollenwerk,
		A. and Kowalewski, S. and Misgeld, B. and Leonhardt, S. and
		Walter, M. },
	title = { Physiological closed-loop control of mechanical ventilation
		and extracorporeal membrane oxygenation” },
	journal = { Biomedical Engineering / Biomedizinische Technik },
	year = { 2017 },
	i11key = { journal },
	i11projectkey = { ECLA-Vent },
	note = { To appear },
	timestamp = { 2017.03.15 },
	for_reporting_period = { 2017 },
}
[KBS+17]
PDFBIB
Kühn, J., Brendle, C., Stollenwerk, A., Schweigler, M., Kowalewski, S., Janisch, T., Rossaint, R., Leonhardt, S., Walter, M., and Kopp, R., "Decentralized safety concept for closed-loop controlled intensive care", Biomedical Engineering / Biomedizinische Technik, vol. 62, pp. 213-223, 2017

Decentralized safety concept for closed-loop controlled intensive care

Bibtex entry :

@article { KBS+17,
	author = { K{\"u}hn, J. and Brendle, C. and Stollenwerk, A. and
		Schweigler, M. and Kowalewski, S. and Janisch, T. and
		Rossaint, R. and Leonhardt, S. and Walter, M. and Kopp, R. },
	title = { Decentralized safety concept for closed-loop controlled
		intensive care },
	journal = { Biomedical Engineering / Biomedizinische Technik },
	year = { 2017 },
	volume = { 62 },
	pages = { 213--223 },
	publisher = { De Gruyter },
	publishedas = { Online Druck },
	issn = { 1862-278X },
	i11key = { journal },
	i11projectkey = { ECLA-Vent },
	language = { eng },
	timestamp = { 2017.03.15 },
	for_reporting_period = { 2017 },
}
[BHK+17]
PDFBIB
Brendle, C., Hackmack, K. -F., Kühn, J., Wardeh, M. N., Janisch, T., Kopp, R., Rossaint, R., Stollenwerk, A., Kowalewski, S., Misgeld, B., Leonhardt, S., and and Walter, M., "Continuous gas transfer monitoring during extracorporeal membrane oxygenation", Biomedical Signal Processing and Control, vol. 31, pp. 321-330, 2017, To appear

Continuous gas transfer monitoring during extracorporeal membrane oxygenation

Bibtex entry :

@article { BHK+17,
	author = { Brendle, C. and Hackmack, K.-F. and K{\"u}hn, J. and Wardeh,
		M.N. and Janisch, T. and Kopp, R. and Rossaint, R. and
		Stollenwerk, A. and Kowalewski, S. and Misgeld, B. and
		Leonhardt, S and and Walter, M. },
	title = { Continuous gas transfer monitoring during extracorporeal
		membrane oxygenation },
	journal = { Biomedical Signal Processing and Control },
	year = { 2017 },
	volume = { 31 },
	pages = { 321--330 },
	publisher = { Elsevier },
	publishedas = { Online Druck },
	issn = { 1746-8094 },
	i11key = { journal },
	i11projectkey = { ECLA-Vent },
	language = { eng },
	note = { To appear },
	timestamp = { 2016.09.15 },
	for_reporting_period = { 2016 },
}
[KSB+16]
Kühn, J., Stollenwerk, A., Brendle, C., Janisch, T., Walter, M., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Sensor Supervision and Control Value Limitations in Networked Intensive Care", in Proc. Fail Safety in Medical Cyber-Physical Systems, 2016, vol. 1559 in Gemeinsamer Tagungsband der Workshops der Tagung Software Engineering 2016 (SE 2016), CEUR Workshop Proceedings, pp. 187-194.

Sensor Supervision and Control Value Limitations in Networked Intensive Care

Bibtex entry :

@inproceedings { KSB+16,
	author = { K{\"u}hn, Jan and Stollenwerk, Andr{\'e} and Brendle,
		Christian and Janisch, Thorsten and Walter, Marian and
		Rossaint, Rolf and Leonhardt, Steffen and Kowalewski, Stefan
		and Kopp, R{\"u}dger },
	editor = { Zimmermann, Wolf and Alperowitz, Lukas and Br{\"u}gge,
		Bernd	and Fahsel, J{\"o}rn and Herrmann, Andrea and
		Hoffmann, Anne and Krall, Andreas and Landes, Dieter and
		Lichter, Horst and Riehle, Dirk and Schaefer, Ina and
		Scheuermann, Constantin and Schlaefer, Alexander and Schupp,
		Sibylle and Seitz, Andreas and Steffens, Andreas and
		Stollenwerk, Andr\'{e} and Wei{/ss}bach, R{/"u}diger },
	title = { Sensor Supervision and Control Value Limitations in
		Networked Intensive Care },
	booktitle = { Fail Safety in Medical Cyber-Physical Systems },
	series = { Gemeinsamer Tagungsband der Workshops der Tagung Software
		Engineering 2016 (SE 2016) },
	number = { 2 },
	volume = { 1559 },
	publisher = { CEUR Workshop Proceedings },
	publishedas = { Online },
	issn = { 1613-0073 },
	language = { eng },
	pages = { 187--194 },
	year = { 2016 },
	timestamp = { 2016.09.15 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://ceur-ws.org/Vol-1559/paper25.pdf },
	for_reporting_period = { 2016 },
}
[KVS+16]
PDFBIB
Kühn, J., Vaitl, L., Stollenwerk, A., Brendle, C., Walter, M., Janisch, T., Leonhardt, S., Kowalewski, S., Rossaint, R., and Kopp, R., "Eingebettete Rezirkulationsmessung für eine ECLA-Therapie", in Proc. AUTOMED Workshop, 2016, To appear.

Eingebettete Rezirkulationsmessung für eine ECLA-Therapie

Bibtex entry :

@conference { KVS+16,
	author = { K{\"u}hn, Jan and Vaitl, Lorenz and Stollenwerk, Andr{\'e}
		and Brendle, Christian and Walter, Marian and Janisch,
		Thorsten and Leonhardt, Steffen and Kowalewski, Stefan and
		Rossaint, Rolf and Kopp, R{\"u}dger },
	title = { Eingebettete Rezirkulationsmessung f{\"u}r eine
		ECLA-Therapie },
	booktitle = { AUTOMED Workshop },
	year = { 2016 },
	timestamp = { 2016.09.15 },
	language = { ger },
	i11projectkey = { ECLA-Vent },
	note = { To appear },
	for_reporting_period = { 2016 },
}
[WBK+16]
PDFBIB
Walter, M., Brendle, C., Kühn, J., Janisch, T., Kopp, R., Stollenwerk, A., and Leonhardt, S., "Assistive Control of Extracorporeal Oxygenation Systems", in Proc. 12th German Russian Conference on Biomedical Engineering, 2016.

Assistive Control of Extracorporeal Oxygenation Systems

Bibtex entry :

@conference { WBK+16,
	author = { Walter, M. and Brendle, C. and K{\"u}hn, J. and Janisch, T.
		and Kopp, R. and Stollenwerk, A. and Leonhardt, S. },
	title = { Assistive Control of Extracorporeal Oxygenation Systems },
	booktitle = { 12th German Russian Conference on Biomedical Engineering },
	year = { 2016 },
	timestamp = { 2016.09.15 },
	language = { eng },
	i11projectkey = { ECLA-Vent },
	for_reporting_period = { 2016 },
}
[DKK16]
Dernehl, C., Kühn, J., and Kowalewski, S., "Abstract Interpretation for Block Diagrams - Two Case Studies", in Proc. 13th Workshop on Model Design, Verification and Validation, 2016, CEUR, pp. 20-29.

Abstract Interpretation for Block Diagrams - Two Case Studies

Bibtex entry :

@inproceedings { DKK16,
	author = { Dernehl, Christian and K{\"u}hn, Jan and Kowalewski, Stefan },
	title = { Abstract Interpretation for Block Diagrams - Two Case
		Studies },
	booktitle = { 13th Workshop on Model Design, Verification and Validation },
	publisher = { CEUR },
	publishedas = { Online },
	language = { eng },
	pages = { 20--29 },
	year = { 2016 },
	timestamp = { 2016.01.18 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://ceur-ws.org/Vol-1713/MoDeVVa_2016_paper_3.pdf },
	for_reporting_period = { 2016 },
}
[KBS+15]
Kühn, J., Brendle, C., Stollenwerk, A., Walter, M., Wardeh, N., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Pulsatile Ansteuerung einer Diagonalblutpumpe", atp edition - Automatisierungstechnische Praxis, vol. 10, pp. 52-59, 2015

Pulsatile Ansteuerung einer Diagonalblutpumpe

Bibtex entry :

@article { KBS+15,
	author = { K{\"u}hn, Jan and Brendle, Christian and Stollenwerk,
		Andr{\'e} and Walter, Marian and Wardeh, Nabil and Rossaint,
		Rolf and Leonhardt, Steffen and Kowalewski, Stefan and Kopp,
		R{\"u}dger },
	title = { Pulsatile Ansteuerung einer Diagonalblutpumpe },
	journal = { atp edition - Automatisierungstechnische Praxis },
	year = { 2015 },
	volume = { 10 },
	pages = { 52--59 },
	publisher = { DIV Deutscher Industrieverlag GmbH },
	publishedas = { Online Druck },
	issn = { 2190-4111 },
	i11key = { journal },
	i11projectkey = { ECLA-Vent },
	language = { eng },
	url = { http://publications.embedded.rwth-aachen.de/file/64 },
	timestamp = { 2015.10.30 },
	for_reporting_period = { 2015 },
}
[BHK+15]
Brendle, C., Hackmack, K., Kühn, J., Wardeh, M. N., Kopp, R., Rossaint, R., Stollenwerk, A., Kowalewski, S., Misgeld, B., Leonhardt, S., and Walter, M., "In silico evaluation of gas transfer estimation during extracorporeal membrane oxygenation", in Proc. 9th IFAC Symposium on Biological and Medical Systems, 2015, vol. 48, IFAC-PapersOnLine, pp. 499-504.

In silico evaluation of gas transfer estimation during extracorporeal membrane oxygenation

Bibtex entry :

@inproceedings { BHK+15,
	doi = { 10.1016/j.ifacol.2015.10.190 },
	author = { Brendle, Christian and Hackmack, Kay-Florian and K{\"u}hn,
		Jan and Wardeh, Markus Nabil and Kopp, R{\"u}dger and
		Rossaint, Rolf and Stollenwerk, Andr{\'e} and Kowalewski,
		Stefan and Misgeld, Berno and Leonhardt, Steffen and Walter,
		Marian },
	title = { In silico evaluation of gas transfer estimation during
		extracorporeal membrane oxygenation },
	booktitle = { 9th IFAC Symposium on Biological and Medical Systems },
	number = { 20 },
	volume = { 48 },
	publisher = { IFAC-PapersOnLine },
	publishedas = { Druck Online },
	issn = { 2405-8963 },
	language = { eng },
	pages = { 499--504 },
	year = { 2015 },
	timestamp = { 2015.05.12 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://www.sciencedirect.com/science/article/pii/S2405896315020819 },
	for_reporting_period = { 2015 },
}
[KWS+15]
Kühn, J., Wübbels, N., Stollenwerk, A., Walter, M., Brendle, C., Wardeh, N., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Pulsatile Ansteuerung einer Diagonalblutpumpe", in Proc. Automation 2015, 2015, VDI Verlag, pp. 325-339.

Pulsatile Ansteuerung einer Diagonalblutpumpe

Bibtex entry :

@inproceedings { KWS+15,
	author = { K{\"u}hn, Jan and W{\"u}bbels, Nico and Stollenwerk, André
		and Walter, Marian and Brendle, Christian and Wardeh, Nabil
		and Rossaint, Rolf and Leonhardt, Steffen and Kowalewski,
		Stefan and Kopp, R{\"u}dger },
	editor = { VDI Wissensforum },
	title = { Pulsatile Ansteuerung einer Diagonalblutpumpe },
	booktitle = { Automation 2015 },
	publisher = { VDI Verlag },
	publishedas = { Druck Online },
	isbn = { 978-3-18-092258-4 },
	language = { ger },
	pages = { 325--339 },
	year = { 2015 },
	timestamp = { 2015.03.25 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://publications.embedded.rwth-aachen.de/file/65 },
	for_reporting_period = { 2015 },
}
[KSS+15]
Kühn, J., Schoonbrood, P., Stollenwerk, A., Walter, M., Brendle, C., Wardeh, N., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Safety Conflict Analysis in Medical Cyber-Physical Systems using an SMT-Solver", in Proc. Fail Safety in Medical Cyber-Physical Systems, 2015, vol. 1337, CEUR Workshop Proceedings, pp. 19-23.

Safety Conflict Analysis in Medical Cyber-Physical Systems using an SMT-Solver

Bibtex entry :

@inproceedings { KSS+15,
	author = { K{\"u}hn, Jan and Schoonbrood, Pierre and Stollenwerk,
		André and Walter, Marian and Brendle, Christian and Wardeh,
		Nabil and Rossaint, Rolf and Leonhardt, Steffen and
		Kowalewski, Stefan and Kopp, R{\"u}dger },
	editor = { Zimmermann, Wolf and B{\"o}hm, Wolfgang and Grelck, Clemens
		and Heinrich, Robert and Jung, Reiner  and Konersmann, Marco
		and Schlaefer, Alexander and Schmieders, Eric and Schupp,
		Sibylle and Trancón Widemann, Baltasar  and Weyer, Thorsten },
	title = { Safety Conflict Analysis in Medical Cyber-Physical Systems
		using an SMT-Solver },
	booktitle = { Fail Safety in Medical Cyber-Physical Systems },
	volume = { 1337 },
	publisher = { CEUR Workshop Proceedings },
	publishedas = { Online },
	issn = { 1613-0073 },
	language = { eng },
	pages = { 19--23 },
	year = { 2015 },
	timestamp = { 2015.02.19 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://publications.embedded.rwth-aachen.de/file/5s },
	for_reporting_period = { 2015 },
}
[SKW+15]
Stollenwerk, A., Kühn, J., Walter, M., Brendle, C., Wardeh, N., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Software-based Prediction of Cannula Occlusion during Extracorporeal Blood Circulation through Networked Medical Data", in Proc. Fail Safety in Medical Cyber-Physical Systems, 2015, vol. 1337, CEUR Workshop Proceedings, pp. 1-6.

Software-based Prediction of Cannula Occlusion during Extracorporeal Blood Circulation through Networked Medical Data

Bibtex entry :

@inproceedings { SKW+15,
	author = { Stollenwerk, Andr{\'e} and K{\"u}hn, Jan and Walter, Marian
		and Brendle, Christian and Wardeh, Nabil and Rossaint, Rolf
		and Leonhardt, Steffen and Kowalewski, Stefan and Kopp,
		R{\"u}dger },
	editor = { Zimmermann, Wolf and B{\"o}hm, Wolfgang and Grelck, Clemens
		and Heinrich, Robert and Jung, Reiner  and Konersmann, Marco
		and Schlaefer, Alexander and Schmieders, Eric and Schupp,
		Sibylle and Trancón Widemann, Baltasar  and Weyer, Thorsten },
	title = { Software-based Prediction of Cannula Occlusion during
		Extracorporeal Blood Circulation through Networked Medical
		Data },
	booktitle = { Fail Safety in Medical Cyber-Physical Systems },
	volume = { 1337 },
	publisher = { CEUR Workshop Proceedings },
	publishedas = { Online },
	issn = { 1613-0073 },
	language = { eng },
	pages = { 1--6 },
	year = { 2015 },
	timestamp = { 2015.02.10 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://publications.embedded.rwth-aachen.de/file/5p },
	for_reporting_period = { 2015 },
}
[SKB+14]
Stollenwerk, A., Kühn, J., Brendle, C., Walter, M., Arens, J., Wardeh, M. N., Kowalewski, S., and Kopp, R., "Model-based supervision of a blood pump", in Proc. 19th World Congress of the International Federation of Automatic Control, 2014, pp. 6593-6598.

Model-based supervision of a blood pump

Bibtex entry :

@inproceedings { SKB+14,
	pages = { 6593-6598 },
	url = { http://publications.embedded.rwth-aachen.de/file/5d },
	author = { Stollenwerk, Andr{\'e} and K{\"u}hn, Jan and Brendle,
		Christian and Walter, Marian and Arens, Jutta and	Wardeh,
		Markus Nabil and Kowalewski, Stefan and Kopp, R{\"u}dger },
	title = { Model-based supervision of a blood pump },
	booktitle = { 19th World Congress of the International Federation of
		Automatic Control },
	year = { 2014 },
	timestamp = { 2014.05.05 },
	language = { eng },
	i11projectkey = { ECLA-Vent },
	for_reporting_period = { 2014 },
}

RWTH Aachen University - Chair of Computer Science 11 - Ahornstr. 55 - 52074 Aachen - Germany