ECLA-VENT

Akutes Lungenversagen (ARDS) ist ein lebensgefährliches Syndrom, das in schweren Fällen den Einsatz von Lungenunterstützunssystemen (ECLA: extracorporal lung assist) bedingt, um die Lebensfunktionen des Patienten aufrechtzuerhalten. ECLA-Systeme unterstützen zusätzlich zur künstlichen Beatmung die geschädigten Atmungsorgane des Patienten durch die direkte Oxygenierung des Blutes (ECMO: extracorporal membrane oxygenation).

Da diese Theraphiemethode kostenintensiv ist und ein hohes Komplikationsrisiko birgt, wird sie lediglich als Ultima-Ratio-Methode verwendet. Eine Automatisierung der Therapie könnte die Anwendbarkeit entscheidend erhöhen. Wesentliche Asperkte wären dieReduzierung der Arbeitsbelastung des Personals und der Reaktionszeit auf Komplikationen. Zusätzlich erlaubt es auch eine besser angepasste Behandlung, zum Beispiel durch kontinuierliche Abstimmung der Beatmung und Blutoxygenierung anhand einer patienbezogenen Strategie.

Aus dieser Motivation lässt sich ein Themenkomplex ableiten, der Forschungsgegenstand des Projektes ECLA-VENT ist. Dieses Projekt wird im Rahmen des Verbundprojektes „Smart Life Support 2.0“ von der deutschen Forschungsgesellschaft (DFG) gefördert.

Projektpartner

Projektziele

Übergeordnetes Ziel des Projektes ist die Reduzierung des Patientenrisikos und Optimierung der Therapieeffizienz durch dynamisch angepasste Behandlungsparameter. Dazu wird in Zusammenarbeit mit unseren Projektpartnern ein kombiniertes Beatmungs- und Oxygenierungsystem auf Basis einer eingebetteten intelligenten Regelung entwickelt.

Hauptaugenmerk unserer Projektpartner ist die Entwicklung einer kooperativen Regelung, die komplexe Behandlungsstrategien erlaubt und aktiv zur Lungenprotektion beiträgt. Unser Forschungsschwerpunkt liegt im Bereich der Sicherheit und Zuverlässigkeit des zugrundeliegenden eingebetteten Systems. Hierbei bildet die kooperative Regelung mit der Physiologie des Patienten ein umfangreiches System nichtlinearer Abhängigkeiten. Entsprechend müssen zusätzliche Sicherheitsanforderungen berücksichtigt werden und die Zielvereinbarungen auf Konfliktpotential hin untersucht und konzeptionell behandelt werden. Die sich daraus entwickelnden Sicherheitsmechanismen sollen nicht nur beschränkend wirken, sondern mit der Regelung bedarfsgerecht interagieren. Die Ergebnisse des Vorgängerprojekts SmartECLA werden hierbei als Grundlage verwendet.

Unsere Ziele im Überblick:

  • Definition, Verifikation und Implementierung eines umfassenden Sicherheitskonzeptes unter Einbeziehung der kooperativen Regelung
    • Einbeziehung der Ventilation in das bestehende Sicherheitskonzept
    • Analyse sicherheitskritischer Zustände anhand hybrider Systemmodelle
    • Strukturierte Bewertung der Konfliktsituation der Sicherheitsziele mittels Risikoanalyse
    • Entscheidungsstrategie zur Bewältigung der Konfliktsituationen
  • Unterstützung der Systementwicklung im Bereich der Regelung durch Formulierung eines Entwurfsmusterkatalogs zur Etablierung von Kooperationspfaden

Hier finden Sie ausgeschriebene Abschlussarbeiten.

Publikationen

Im Rahmen des Projektes ECLA-VENT entstandene Publikationen


Publikations-Export
[BMK+17]
PDFBIB
Brendle, C., Mülders, T., Kühn, J., Janisch, T., Kopp, R., Rossaint, R., Stollenwerk, A., Kowalewski, S., Misgeld, B., Leonhardt, S., and Walter, M., "Physiological closed-loop control of mechanical ventilation and extracorporeal membrane oxygenation”", Biomedical Engineering / Biomedizinische Technik, 2017, To appear

Physiological closed-loop control of mechanical ventilation and extracorporeal membrane oxygenation”

Bibtex entry :

@article { BMK+17,
	author = { Brendle, C. and M{\"u}lders, T. and K{\"u}hn, J. and
		Janisch, T. and Kopp, R. and Rossaint, R. and Stollenwerk,
		A. and Kowalewski, S. and Misgeld, B. and Leonhardt, S. and
		Walter, M. },
	title = { Physiological closed-loop control of mechanical ventilation
		and extracorporeal membrane oxygenation” },
	journal = { Biomedical Engineering / Biomedizinische Technik },
	year = { 2017 },
	i11key = { journal },
	i11projectkey = { ECLA-Vent },
	note = { To appear },
	timestamp = { 2017.03.15 },
	for_reporting_period = { 2017 },
}
[KBS+17]
PDFBIB
Kühn, J., Brendle, C., Stollenwerk, A., Schweigler, M., Kowalewski, S., Janisch, T., Rossaint, R., Leonhardt, S., Walter, M., and Kopp, R., "Decentralized safety concept for closed-loop controlled intensive care", Biomedical Engineering / Biomedizinische Technik, vol. 62, pp. 213-223, 2017

Decentralized safety concept for closed-loop controlled intensive care

Bibtex entry :

@article { KBS+17,
	author = { K{\"u}hn, J. and Brendle, C. and Stollenwerk, A. and
		Schweigler, M. and Kowalewski, S. and Janisch, T. and
		Rossaint, R. and Leonhardt, S. and Walter, M. and Kopp, R. },
	title = { Decentralized safety concept for closed-loop controlled
		intensive care },
	journal = { Biomedical Engineering / Biomedizinische Technik },
	year = { 2017 },
	volume = { 62 },
	pages = { 213--223 },
	publisher = { De Gruyter },
	publishedas = { Online Druck },
	issn = { 1862-278X },
	i11key = { journal },
	i11projectkey = { ECLA-Vent },
	language = { eng },
	timestamp = { 2017.03.15 },
	for_reporting_period = { 2017 },
}
[BHK+17]
PDFBIB
Brendle, C., Hackmack, K. -F., Kühn, J., Wardeh, M. N., Janisch, T., Kopp, R., Rossaint, R., Stollenwerk, A., Kowalewski, S., Misgeld, B., Leonhardt, S., and and Walter, M., "Continuous gas transfer monitoring during extracorporeal membrane oxygenation", Biomedical Signal Processing and Control, vol. 31, pp. 321-330, 2017, To appear

Continuous gas transfer monitoring during extracorporeal membrane oxygenation

Bibtex entry :

@article { BHK+17,
	author = { Brendle, C. and Hackmack, K.-F. and K{\"u}hn, J. and Wardeh,
		M.N. and Janisch, T. and Kopp, R. and Rossaint, R. and
		Stollenwerk, A. and Kowalewski, S. and Misgeld, B. and
		Leonhardt, S and and Walter, M. },
	title = { Continuous gas transfer monitoring during extracorporeal
		membrane oxygenation },
	journal = { Biomedical Signal Processing and Control },
	year = { 2017 },
	volume = { 31 },
	pages = { 321--330 },
	publisher = { Elsevier },
	publishedas = { Online Druck },
	issn = { 1746-8094 },
	i11key = { journal },
	i11projectkey = { ECLA-Vent },
	language = { eng },
	note = { To appear },
	timestamp = { 2016.09.15 },
	for_reporting_period = { 2016 },
}
[KSB+16]
Kühn, J., Stollenwerk, A., Brendle, C., Janisch, T., Walter, M., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Sensor Supervision and Control Value Limitations in Networked Intensive Care", in Proc. Fail Safety in Medical Cyber-Physical Systems, 2016, vol. 1559 in Gemeinsamer Tagungsband der Workshops der Tagung Software Engineering 2016 (SE 2016), CEUR Workshop Proceedings, pp. 187-194.

Sensor Supervision and Control Value Limitations in Networked Intensive Care

Bibtex entry :

@inproceedings { KSB+16,
	author = { K{\"u}hn, Jan and Stollenwerk, Andr{\'e} and Brendle,
		Christian and Janisch, Thorsten and Walter, Marian and
		Rossaint, Rolf and Leonhardt, Steffen and Kowalewski, Stefan
		and Kopp, R{\"u}dger },
	editor = { Zimmermann, Wolf and Alperowitz, Lukas and Br{\"u}gge,
		Bernd	and Fahsel, J{\"o}rn and Herrmann, Andrea and
		Hoffmann, Anne and Krall, Andreas and Landes, Dieter and
		Lichter, Horst and Riehle, Dirk and Schaefer, Ina and
		Scheuermann, Constantin and Schlaefer, Alexander and Schupp,
		Sibylle and Seitz, Andreas and Steffens, Andreas and
		Stollenwerk, Andr\'{e} and Wei{/ss}bach, R{/"u}diger },
	title = { Sensor Supervision and Control Value Limitations in
		Networked Intensive Care },
	booktitle = { Fail Safety in Medical Cyber-Physical Systems },
	series = { Gemeinsamer Tagungsband der Workshops der Tagung Software
		Engineering 2016 (SE 2016) },
	number = { 2 },
	volume = { 1559 },
	publisher = { CEUR Workshop Proceedings },
	publishedas = { Online },
	issn = { 1613-0073 },
	language = { eng },
	pages = { 187--194 },
	year = { 2016 },
	timestamp = { 2016.09.15 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://ceur-ws.org/Vol-1559/paper25.pdf },
	for_reporting_period = { 2016 },
}
[KVS+16]
PDFBIB
Kühn, J., Vaitl, L., Stollenwerk, A., Brendle, C., Walter, M., Janisch, T., Leonhardt, S., Kowalewski, S., Rossaint, R., and Kopp, R., "Eingebettete Rezirkulationsmessung für eine ECLA-Therapie", in Proc. AUTOMED Workshop, 2016, To appear.

Eingebettete Rezirkulationsmessung für eine ECLA-Therapie

Bibtex entry :

@conference { KVS+16,
	author = { K{\"u}hn, Jan and Vaitl, Lorenz and Stollenwerk, Andr{\'e}
		and Brendle, Christian and Walter, Marian and Janisch,
		Thorsten and Leonhardt, Steffen and Kowalewski, Stefan and
		Rossaint, Rolf and Kopp, R{\"u}dger },
	title = { Eingebettete Rezirkulationsmessung f{\"u}r eine
		ECLA-Therapie },
	booktitle = { AUTOMED Workshop },
	year = { 2016 },
	timestamp = { 2016.09.15 },
	language = { ger },
	i11projectkey = { ECLA-Vent },
	note = { To appear },
	for_reporting_period = { 2016 },
}
[WBK+16]
PDFBIB
Walter, M., Brendle, C., Kühn, J., Janisch, T., Kopp, R., Stollenwerk, A., and Leonhardt, S., "Assistive Control of Extracorporeal Oxygenation Systems", in Proc. 12th German Russian Conference on Biomedical Engineering, 2016.

Assistive Control of Extracorporeal Oxygenation Systems

Bibtex entry :

@conference { WBK+16,
	author = { Walter, M. and Brendle, C. and K{\"u}hn, J. and Janisch, T.
		and Kopp, R. and Stollenwerk, A. and Leonhardt, S. },
	title = { Assistive Control of Extracorporeal Oxygenation Systems },
	booktitle = { 12th German Russian Conference on Biomedical Engineering },
	year = { 2016 },
	timestamp = { 2016.09.15 },
	language = { eng },
	i11projectkey = { ECLA-Vent },
	for_reporting_period = { 2016 },
}
[DKK16]
Dernehl, C., Kühn, J., and Kowalewski, S., "Abstract Interpretation for Block Diagrams - Two Case Studies", in Proc. 13th Workshop on Model Design, Verification and Validation, 2016, CEUR, pp. 20-29.

Abstract Interpretation for Block Diagrams - Two Case Studies

Bibtex entry :

@inproceedings { DKK16,
	author = { Dernehl, Christian and K{\"u}hn, Jan and Kowalewski, Stefan },
	title = { Abstract Interpretation for Block Diagrams - Two Case
		Studies },
	booktitle = { 13th Workshop on Model Design, Verification and Validation },
	publisher = { CEUR },
	publishedas = { Online },
	language = { eng },
	pages = { 20--29 },
	year = { 2016 },
	timestamp = { 2016.01.18 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://ceur-ws.org/Vol-1713/MoDeVVa_2016_paper_3.pdf },
	for_reporting_period = { 2016 },
}
[KBS+15]
Kühn, J., Brendle, C., Stollenwerk, A., Walter, M., Wardeh, N., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Pulsatile Ansteuerung einer Diagonalblutpumpe", atp edition - Automatisierungstechnische Praxis, vol. 10, pp. 52-59, 2015

Pulsatile Ansteuerung einer Diagonalblutpumpe

Bibtex entry :

@article { KBS+15,
	author = { K{\"u}hn, Jan and Brendle, Christian and Stollenwerk,
		Andr{\'e} and Walter, Marian and Wardeh, Nabil and Rossaint,
		Rolf and Leonhardt, Steffen and Kowalewski, Stefan and Kopp,
		R{\"u}dger },
	title = { Pulsatile Ansteuerung einer Diagonalblutpumpe },
	journal = { atp edition - Automatisierungstechnische Praxis },
	year = { 2015 },
	volume = { 10 },
	pages = { 52--59 },
	publisher = { DIV Deutscher Industrieverlag GmbH },
	publishedas = { Online Druck },
	issn = { 2190-4111 },
	i11key = { journal },
	i11projectkey = { ECLA-Vent },
	language = { eng },
	url = { http://publications.embedded.rwth-aachen.de/file/64 },
	timestamp = { 2015.10.30 },
	for_reporting_period = { 2015 },
}
[BHK+15]
Brendle, C., Hackmack, K., Kühn, J., Wardeh, M. N., Kopp, R., Rossaint, R., Stollenwerk, A., Kowalewski, S., Misgeld, B., Leonhardt, S., and Walter, M., "In silico evaluation of gas transfer estimation during extracorporeal membrane oxygenation", in Proc. 9th IFAC Symposium on Biological and Medical Systems, 2015, vol. 48, IFAC-PapersOnLine, pp. 499-504.

In silico evaluation of gas transfer estimation during extracorporeal membrane oxygenation

Bibtex entry :

@inproceedings { BHK+15,
	doi = { 10.1016/j.ifacol.2015.10.190 },
	author = { Brendle, Christian and Hackmack, Kay-Florian and K{\"u}hn,
		Jan and Wardeh, Markus Nabil and Kopp, R{\"u}dger and
		Rossaint, Rolf and Stollenwerk, Andr{\'e} and Kowalewski,
		Stefan and Misgeld, Berno and Leonhardt, Steffen and Walter,
		Marian },
	title = { In silico evaluation of gas transfer estimation during
		extracorporeal membrane oxygenation },
	booktitle = { 9th IFAC Symposium on Biological and Medical Systems },
	number = { 20 },
	volume = { 48 },
	publisher = { IFAC-PapersOnLine },
	publishedas = { Druck Online },
	issn = { 2405-8963 },
	language = { eng },
	pages = { 499--504 },
	year = { 2015 },
	timestamp = { 2015.05.12 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://www.sciencedirect.com/science/article/pii/S2405896315020819 },
	for_reporting_period = { 2015 },
}
[KWS+15]
Kühn, J., Wübbels, N., Stollenwerk, A., Walter, M., Brendle, C., Wardeh, N., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Pulsatile Ansteuerung einer Diagonalblutpumpe", in Proc. Automation 2015, 2015, VDI Verlag, pp. 325-339.

Pulsatile Ansteuerung einer Diagonalblutpumpe

Bibtex entry :

@inproceedings { KWS+15,
	author = { K{\"u}hn, Jan and W{\"u}bbels, Nico and Stollenwerk, André
		and Walter, Marian and Brendle, Christian and Wardeh, Nabil
		and Rossaint, Rolf and Leonhardt, Steffen and Kowalewski,
		Stefan and Kopp, R{\"u}dger },
	editor = { VDI Wissensforum },
	title = { Pulsatile Ansteuerung einer Diagonalblutpumpe },
	booktitle = { Automation 2015 },
	publisher = { VDI Verlag },
	publishedas = { Druck Online },
	isbn = { 978-3-18-092258-4 },
	language = { ger },
	pages = { 325--339 },
	year = { 2015 },
	timestamp = { 2015.03.25 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://publications.embedded.rwth-aachen.de/file/65 },
	for_reporting_period = { 2015 },
}
[KSS+15]
Kühn, J., Schoonbrood, P., Stollenwerk, A., Walter, M., Brendle, C., Wardeh, N., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Safety Conflict Analysis in Medical Cyber-Physical Systems using an SMT-Solver", in Proc. Fail Safety in Medical Cyber-Physical Systems, 2015, vol. 1337, CEUR Workshop Proceedings, pp. 19-23.

Safety Conflict Analysis in Medical Cyber-Physical Systems using an SMT-Solver

Bibtex entry :

@inproceedings { KSS+15,
	author = { K{\"u}hn, Jan and Schoonbrood, Pierre and Stollenwerk,
		André and Walter, Marian and Brendle, Christian and Wardeh,
		Nabil and Rossaint, Rolf and Leonhardt, Steffen and
		Kowalewski, Stefan and Kopp, R{\"u}dger },
	editor = { Zimmermann, Wolf and B{\"o}hm, Wolfgang and Grelck, Clemens
		and Heinrich, Robert and Jung, Reiner  and Konersmann, Marco
		and Schlaefer, Alexander and Schmieders, Eric and Schupp,
		Sibylle and Trancón Widemann, Baltasar  and Weyer, Thorsten },
	title = { Safety Conflict Analysis in Medical Cyber-Physical Systems
		using an SMT-Solver },
	booktitle = { Fail Safety in Medical Cyber-Physical Systems },
	volume = { 1337 },
	publisher = { CEUR Workshop Proceedings },
	publishedas = { Online },
	issn = { 1613-0073 },
	language = { eng },
	pages = { 19--23 },
	year = { 2015 },
	timestamp = { 2015.02.19 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://publications.embedded.rwth-aachen.de/file/5s },
	for_reporting_period = { 2015 },
}
[SKW+15]
Stollenwerk, A., Kühn, J., Walter, M., Brendle, C., Wardeh, N., Rossaint, R., Leonhardt, S., Kowalewski, S., and Kopp, R., "Software-based Prediction of Cannula Occlusion during Extracorporeal Blood Circulation through Networked Medical Data", in Proc. Fail Safety in Medical Cyber-Physical Systems, 2015, vol. 1337, CEUR Workshop Proceedings, pp. 1-6.

Software-based Prediction of Cannula Occlusion during Extracorporeal Blood Circulation through Networked Medical Data

Bibtex entry :

@inproceedings { SKW+15,
	author = { Stollenwerk, Andr{\'e} and K{\"u}hn, Jan and Walter, Marian
		and Brendle, Christian and Wardeh, Nabil and Rossaint, Rolf
		and Leonhardt, Steffen and Kowalewski, Stefan and Kopp,
		R{\"u}dger },
	editor = { Zimmermann, Wolf and B{\"o}hm, Wolfgang and Grelck, Clemens
		and Heinrich, Robert and Jung, Reiner  and Konersmann, Marco
		and Schlaefer, Alexander and Schmieders, Eric and Schupp,
		Sibylle and Trancón Widemann, Baltasar  and Weyer, Thorsten },
	title = { Software-based Prediction of Cannula Occlusion during
		Extracorporeal Blood Circulation through Networked Medical
		Data },
	booktitle = { Fail Safety in Medical Cyber-Physical Systems },
	volume = { 1337 },
	publisher = { CEUR Workshop Proceedings },
	publishedas = { Online },
	issn = { 1613-0073 },
	language = { eng },
	pages = { 1--6 },
	year = { 2015 },
	timestamp = { 2015.02.10 },
	i11key = { conference },
	i11projectkey = { ECLA-Vent },
	url = { http://publications.embedded.rwth-aachen.de/file/5p },
	for_reporting_period = { 2015 },
}
[SKB+14]
Stollenwerk, A., Kühn, J., Brendle, C., Walter, M., Arens, J., Wardeh, M. N., Kowalewski, S., and Kopp, R., "Model-based supervision of a blood pump", in Proc. 19th World Congress of the International Federation of Automatic Control, 2014, pp. 6593-6598.

Model-based supervision of a blood pump

Bibtex entry :

@inproceedings { SKB+14,
	pages = { 6593-6598 },
	url = { http://publications.embedded.rwth-aachen.de/file/5d },
	author = { Stollenwerk, Andr{\'e} and K{\"u}hn, Jan and Brendle,
		Christian and Walter, Marian and Arens, Jutta and	Wardeh,
		Markus Nabil and Kowalewski, Stefan and Kopp, R{\"u}dger },
	title = { Model-based supervision of a blood pump },
	booktitle = { 19th World Congress of the International Federation of
		Automatic Control },
	year = { 2014 },
	timestamp = { 2014.05.05 },
	language = { eng },
	i11projectkey = { ECLA-Vent },
	for_reporting_period = { 2014 },
}

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